Meet Our Protein Characterization Problem Solver
Microflow Imaging (MFI™)
Subvisible particle analysis for biopharmaceuticals
Micro-Flow Imaging: Image-based Particle Analysis for Biopharmaceuticals
MFI gives you more insight into the world of sub-visible particles—way more than just size and count. Because it's image-based, you can add quantifiable morphological parameters to your analysis. You'll be differentiating particle populations from each other and classifying them in no time. Plus, it's got an optic focal length that spans the entire fluidic path, so your sample data is robust and reproducible day in and day out. Add a Bot1 anytime to automate the whole process and kick your throughput up a notch. If you're looking for broader, deeper analysis of your biotherapeutic products, MFI is the particle analysis tool for you.
What MFI can do for you?
- Precise and quantitative characterization of particle size, concentration and morphology
- Differentiate particle populations within your sample
- Measure translucent protein aggregates
- Automate runs for up to 96 samples
- Get quantitative data in less than 10 minutes per sample
Applications
Specifications
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| Description | MFI 5100 | MFI 5200 |
|---|---|---|
| Size Range | 2 to 300 µm | 1 to 70 µm |
| Percent of Sample Analyzed | >85% — entire size range | >85% — entire size range |
| Depth of Field (DOF) | 400 µm | 100 µm |
| Flow Cell Depth | 400 µm — DOF matched | 100 µm — DOF matched |
| Analysis Rate | 200 µL/min | 150 µL/min |
| Maximum Concentration (@2.5 µm) | 175,000 particles/mL | 900,000 particles/mL |
| Automation | High Throughput Bot1 Autosampler (optional) | |
| Sample Loading Options | Pipette tip: 1 mL manual insertion, 1 mL Autosampler Syringe barrel | |
| 2 mL, 10 mL, 20 mL manual insertion | ||
| BD Hypak™ Syringe Introduction Adapter: 1 mL, 2 mL | ||
| Flow Cell Coatings | Non-coated, hydrophobic, custom | |
| Precision Stirring | Variable speed control: 200-2,000 RPM | |
| Compatible with syringe barrel usage | ||
| Data Output | Chart formats: histograms, scatterplots, trend charts | |
| Image formats: uncompressed TIFF(analysis), compressed JPG(storage) | ||
| Particle Count Parameters | Particle count, concentration, mass, volume | |
| Morphology Parameters | Size (ECD), maximum feret diameter, aspect ratio, circularity, area, perimeter, intensity | |
| Customized Analysis Filters | Combine two or more image and count parameters in a filter, for up to 511 different custom analysis filters | |
| MFI View System Software (MVSS) See product brochure for full details | Method-based analysis protocols | |
| Time - resolved analysis and data compression for storage | ||
| 21 CFR Part 11 enabling features | ||
| Secure access with comprehensive audit / log files | ||
| Fully compatible with MFI View Analysis Suite(MVAS) | ||
| MFI View Analysis Suite (MVAS) See product brochure for full details | Review images, parametric data and trend charts | |
| Isolate sub - populations using find - similar function | ||
| Create multi - node filters with real - time feedback | ||
| Overlay and compare data sets | ||
| Generate comprehensive reports with multiple categories | ||
| Create analysis templates for repeat use | ||
| Dimensions | MFI 5000 Alone: 23.97 in W X 17.01 in D X 12.00 in H | |
| With Bot1 Autosampler: 23.97 in W X 17.01 in D X 26.20 in H | ||
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